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called her "drop-dead gorgeous." The slow but steady arc of Pfeiffer's career began in Orange County, California. I went to school with Paul Newman, and we are very old friends.She was a regular Southern California girl, who surfed at Huntington Beach, hung out at Life Guard Station 17, and went to boarding school in Colorado Springs. Finally, we did a picture together, and one day, after a lot of beers, Paul said, "You know, my recurring nightmare is that one morning I'm going to wake up, and my eyes will have turned brown." Paul saw his whole success in terms of the color of his eyes.Her mom was a homemaker, her dad an air-conditioning contractor.

We came out here but because of a bus strike, our transfer tickets don't work and we can't get back downtown. ' I reached into my pocket and gave him all the money I had.), at whose office in Burbank, Calif., we are meeting. “We won’t be long, I promise,” Pfeiffer tells him as she leads me to a room across the hall, laughing flirtatiously, a woman used to handling men.She settles in next to an open window, looking ethereally beautiful in the afternoon sun, casually dressed in slim, tailored black jeans and a beige silk blouse worn unbuttoned over a fitted white T-shirt.It is, in fact, something of a camp classic, enjoyable on its own terms and boasting a marvellously insouciant performance from Pfeiffer as the leader of the Pink Ladies.(The plot is a rerun of the original, albeit with a gender reversal.




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We propose that the lack of functional conservation for mouse Prdm1, that can nevertheless partially rescue the adaxial cells of zebra fish Cellular processes such as tissue differentiation are coordinated by the controlled expression of regulatory proteins that trigger specific gene expression programs. Indeed, the mouse Prdm1 protein can rescue the phenotype of a zebra fish is expressed in adaxial cells (Baxendale et al. Detailed analysis of the phenotype has shown that adaxial cells still differentiate into muscle but fail to activate the slow program and express fast muscle markers (Roy et al. Prdm1, acting downstream of Hedgehog signaling (Baxendale et al. It also promotes the onset of the slow program by repressing the expression of the transcriptional repressor Sox6 (von Hofsten et al. Interestingly, mouse mutants are characterized by the failure to repress the expression of the slow myosin heavy chain in fetal fibers, indicating that in the mouse Sox6 also acts as a repressor of the slow program at later stages (Hagiwara et al. In the mouse embryo, it has been shown recently that Six1 and Six4 homeodomain transcription factors, that regulate muscle progenitor cell behavior at the level of Pax3 and the myogenic regulatory factors, are required for the correct expression of fast muscle genes in the myotome (Niro et al. In the absence of Six1 and Six4, the slow program is normally activated, but fast genes fail to be expressed.


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